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Ipamorelin may cause mild water retention or bloating in some patients because growth hormone signaling affects fluid balance

The medication enhances glucose-dependent insulin secretion from pancreatic beta cells, meaning it stimulates insulin release only when blood glucose levels are elevated, thereby reducing the risk of hypoglycemia

The article explains that these medications work partly by resetting appetite centers in the brain, so when the drug is withdrawn suddenly, appetite hormones and metabolic signaling return to their baseline patterns and can trigger compensatory overeating

Brighten: also think that it's It's a misunderstanding that these are only used for diabetes and that weight loss is a vanity metric that people are after